Hereditary FACTOR VII Deficiency: About Two Cases

Authors

  • Loubna Darfaoui Faculty of Medicine and Pharmacy of Marrakech, Cadi Aayad University, Marrakech , Morocco,Hematology Department of Avicenna Military Hospital of Marrakech, Marrakech , Morocco Loubna DARFAOUI, Medical Biologist
  • Hajar Safour Faculty of Medicine and Pharmacy of Marrakech, Cadi Aayad University, Marrakech , Morocco,Hematology Department of Avicenna Military Hospital of Marrakech, Marrakech , Morocco Loubna DARFAOUI, Medical Biologist
  • Hicham Yahyaoui Faculty of Medicine and Pharmacy of Marrakech, Cadi Aayad University, Marrakech , Morocco,Hematology Department of Avicenna Military Hospital of Marrakech, Marrakech , Morocco Loubna DARFAOUI, Medical Biologist
  • Mustapha Ait Ameur Faculty of Medicine and Pharmacy of Marrakech, Cadi Aayad University, Marrakech , Morocco,Hematology Department of Avicenna Military Hospital of Marrakech, Marrakech , Morocco Loubna DARFAOUI, Medical Biologist
  • Mohameed Chakour Faculty of Medicine and Pharmacy of Marrakech, Cadi Aayad University, Marrakech , Morocco,Hematology Department of Avicenna Military Hospital of Marrakech, Marrakech , Morocco Loubna DARFAOUI, Medical Biologist

Keywords:

Coagulation factor VII, Hereditary deficiency, hemorrhagic manifestations

Abstract

Coagulation factor VII or proconvertin is a vitamin K dependent glycoprotein synthesized by the liver. This factor initiates the coagulation cascade by binding to tissue factor after a vascular breach. A qualitative or quantitative deficiency in this factor can cause hemorrhagic manifestations of varying severity. Hereditary factor VII deficiency is a rare disease. The clinical symptomatology is very variable and not correlated to the deficiency in this factor. It can be fatal with a severe hemorrhagic syndrome. An isolated prolongation of the prothrombin time is the first assessment that points to this diagnosis and a low level of plasma factor VII activity confirms it. The Treatment is very complex, hence the importance of collaboration between clinicians and biologists.

References

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. RESERVES IU-TD. Orphanet: Déficit congénital en facteur VII [Internet]. [cité 1 janv 2022]. Disponible sur: https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=FR&Expert=327

. Şenol BK, Zülfikar B. Clinical problems and surgical interventions in inherited factor VII deficiency. Turk Pediatri Ars. 2020;55(2):184 90.

. Robinson KS. An overview of inherited factor VII deficiency. Transfus Apher Sci. oct 2019;58(5):569 71.

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Published

2022-04-25

How to Cite

Loubna Darfaoui, Hajar Safour, Yahyaoui, H., Ait Ameur, M., & Chakour, M. (2022). Hereditary FACTOR VII Deficiency: About Two Cases. International Journal of Natural Sciences: Current and Future Research Trends, 13(1), 49–51. Retrieved from https://ijnscfrtjournal.isrra.org/index.php/Natural_Sciences_Journal/article/view/1097

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